Abstract:Objective To investigate the relationship between serum uric acid level and carotid intima media thickness as an early indicator of arterial stiffness. Methods A total of 5 440 cases of a mine workers aged ≥40 years were randomly divided into two groups according to the level of serum uric acid. The relationship between serum uric acid and cIMT was analyzed by multivariate analysis. Results(1)5 294 participants were included in the study: non-hyperuricemia group 4 739 cases(89.5%),hyperuricemia group 555 cases(10.5%).(2)Mean age,cIMT,BMI,SBP,Log-TG,TC,Cr levels, and percentage of drinking,high salt diet, and extent of exercise in the hyperuricemia group were higher than those in the non-hyperuricemia group and he difference was statistically significant(P<0.05).(3)Multiple linear regression showed that as serum uric acid increased by 1 mg/dL after adjustment for relevant factors, carotid intima-media thickness increased in the following fashion: general population 0.01 mm(95%CI 0.01~0.01,P<0.05), women 0.03 mm(95%CI 0.02~0.04,P<0.05). and men 0.00 mm(95%CI 0.00~0.01,P=0.072),respectively.(4)Logistic multivariate regression analysis showed that after adjustment for relevant factors,the risk of cIMT≥1 mm in the hyperuricemia group was higher than that in the non-hyperuricemia group. The ORs were 1.27(95%CI 1.01~1.60,P<0.05)in all participants,1.99(95%CI 1.29~3.06,P<0.05)in female participants,1.06(95%CI 0.81~1.39,P=0.67)in male participants. Conclusions In women the level of serum uric acid is related to carotid intima media thickening,and hyperuricemia may more likely lead to develop atherosclerosis.