Abstract:ObjectiveTo discuss the level of COMP in serum of AS patients and its correlation with disease activity.MethodsThis study collected 60 patients with ankylosing spondylitis(30 in each active and inactive group)and 30 in healthy control group.To detect the COMP concentration in serum of AS patients, healthy control group and the COMP concentration of 12 active AS patients(active group)before and after 24 weeks of treatment.At the same time, the levels of ESR, CRP and other laboratory indicators in patients’ serum were detected, and sacroiliac joint CT grading was performed.To analyze the serum COMP level between three groups, and the correlation between serum COMP and other laboratory indicators was analyzed.ResultsThe serum COMP level in the active group was higher than that in the inactive and the healthy control group(P<0.05).The serum COMP level in the inactive group was higher than that in the healthy patients(P<0.05).Correlation analysis showed that serum COMP level was positively correlated with BASDAI and VAS of spinal pain(P<0.05), but was not significantly correlated with age, course of disease, ESR, CRP, GLB and CT grade(P>0.05).ConclusionsSerum COMP can reflect inflammation and disease activity of AS patients.Combined with serum CRP and ESR results, it can better evaluate inflammation reaction, disease activity and guide treatment of AS patients.