Abstract:ObjectiveTo discover the relationship between chorioamnionitis, and neurodevelopmental outcome in preterm infants.MethodsPremature newborns(≤34 weeks)were selected in our hospital during from March 2014 to March 2016.All the infants were checked by magnetic resonance imaging(MRI)to determine whether there is brain injury.The gender, gestational age, birth weight, Apgar score of 1 and 5 minute, RDS, and chorioamnionitis were analyzed through team study to find the risk factors of premature brain injury.All the premature babies were followed up covering the time from discharge to 2 years old of corrected gestational age and received Gesell accessment.Result194 individuals completed the follow-up.OR value of brain injury for less than 32 weeks, less than 1 500 g, present of RDS, less than 7 score at 1 or 5 minute and present of chorioamnionitis are 3.07(1.72-5.49), 2.93(1.59-5.40),6.20(3.14-12.25),2.97(1.54-5.72),11.4(2.53-51.35), 3.38(1.79-6.02)respectively, P<0.05.OR value of brain injury for gender is 1.26(0.72-2.21), P>0.05.The incidence of brain injure increased 1.21 times while the gestational age decreased 2 weeks.The incidence of brain injure increased 0.92 times while the chorioamnionitis increased one degree.Brain injure increase the neurodevelopmental disorders at 2 years old of corrected gestational age.ConclusionsSmall gestational age, light birth weight, RDS, lower Apgar scores at 1 or 5 minute and chorioamnionitis are related to increasing incidence of brain injury.Brain injury has certain predictive value for developmental disorders of premature infants.