ObjectiveTo compare the expression of alveolar macrophages membrane receptor SRA mRNA, stimulated by Porphyromonas gingivalis lipopolysaccharide(PgLPS) in healthy and hyperlipidemic rabbit, and detect the effect of interleukin10(IL10).Methods12 healthy New Zealand rabbits were randomly divided into two groups, and respectively gave them normal and high fat diets.After 6 weeks, hyperlipidemia model was established.Alveolar macrophages (AM) of both healthy and hyperlipidemia groups were isolated by alveolar lavage and then further divided into three groups: control, 1 μg/mL PgLPS and 1 μg/mL PgLPS+0.1 μg/mL IL10.After the treatment with PgLPS and IL10 for 24 hours, the mRNA expression levels of SRA in all samples were detected by realtime fluorescence quantitative polymerase chain reaction(PCR).ResultsResults of realtime PCR showed that the level of SRA on both healthy and hyperlipidemic rabbit AM were significantly increased (P<0.05) by PgLPS when compared with control group.Moreover, the increasing of SRA level in hyperlipidemic PgLPS group was more prominent than in healthy PgLPS group(P<0.05).Furthermore, when compared with that in PgLPS group, IL10 induced higher SRA expression in healthy group and lower SRA expression in hyperlipidemic group (P<0.05).ConclusionPeriodontal pathogen PgLPS might increase the risk of atherosclerosis by stimulating the expression of alveolar macrophages membrane receptor SRA in hyperlipidemia, and this stimulation could be negatively regulated by IL10.