ObjectiveTo investigate the effect of Xueshuan Xinmaining on the expression of vascular endothelial growth factor（VEGF）in rats with focal cerebral ischemiareperfusion.MethodRats were randomly assigned into three groups: sham operation group(sham group), focal cerebral ischemiareperfusion group(model group) and Xueshuan Xinmaining group (test group).Before making a model, the rats in the test group were lavaged with Xueshuan Xinmaining 800 mg/kg, once a day for 6 consecutive days.The middle cerebral artery occlusion reperfusion model was made by the suture method (ischemia for 1 hours, and reperfusion for 24 hours).The level of VEGF expression were measured by immunohistochemistry and PCR.ResultsThe expression of VEGF in the rats of test group was higher than that in model group(P<0.05).ConclusionXueshuan Xinmaining can relieve the brain damage partly by enhancing VEGF synthesis in brain.