ObjectiveTo investigate the relationship between the levels of serum procalcitonin (PCT) and high sensitivity C reactive protein (hsCRP) and stroke associated pneumonia（SAP）.Methods106 patients with acute stroke were consecutively enrolled.The levels of serum PCI and hsCRP were dynamically tested, and clinical pulmonary infection scores（PSI）was assessed.75 patients with strokeassociated pneumonia（SAP）were divided into the serious and mild SAP group according to PSI.The levels of serum PCI and hsCRP were compared among these groups（including SAP and nonSAP group, normal control group）.ResultsThe concentrations of serum PCI and hsCRP in SAP group were significantly higher than that of nonSAP and normal control group, respectively（P<0.05）.The concentrations and durations of serum PCI and hsCRP in serious SAP group was significantly higher and longer than that of mild SAP group, respectively（P<0.05）.There was significantly correlation between PTC with PSI scorers on 5 and 7 d poststroke.Also, the positive statistical correlation was found between hsCRP levels and PSI scorers on 3, 5 and 7 d postSAP.The optimal cutoff point for the PCT and hsCRP level as determined by the ROC analysis was 3.5 μg/L and 8.1 mg/L, respectively (PCT: sensitivity 94%, specificity 90%; hsCRP: sensitivity 91%, specificity 75%).ConclusionsThe combined assessment of serum PCT and hsCRP can be a biological marker for early diagnosis and prognosis of SAP.