ObjectiveTo investigate a possible warfarin dosing model to guide the individualized therapeutic anticoagulation with warfarin in Fujian Han population.MethodsThe PCR-hybridization was used for genotyping of Cytochrome P450 2C9*1/*3(CYP2C9*1/*3) and vitamin K epoxide reductase complex subunit 1-1639-A/G (VKORC1-1639-A/G) in patients taking oral warfarin anticoagulation.We collected the patients’ clinical information including age, gender, height, weight and stable warfarin dose.ResultsThe warfarin dose predicting formula is deduced by the analysis of the multiple linear regression.The established multiple linear regression model, which contained age, body mass index, CYP2C9*1/*3 and VKORC1-1639-A/G genotype, could explain the inter-individual difference in warfarin dose about 21.2%~20.9%.ConclusionThe warfarin dosing formula based on clinical and pharmacogenomics will help to effectively improve the clinical safety of warfarin anticoagulation.