Objective To investigate the feasibility and safety of radiofrequency catheter ablation combined with left atrial appendage occlusion for the treatment of persistent atrial fibrillation. Methods A persistent atrial fibrillation patient with high risk of thromboembolism and bleeding, suffering from palpitations and short breath, underwent left atrial appendage closure following radiofrequency catheter ablation, and the outcomes and complications were observed. After the procedure, anticoagulation with warfarin was given for 45 days followed by dual antiplatelet therapy with aspirin and clopidogrel. The patient was followed-up for 3 months to observe the improvement of symptoms, bleeding and thrombotic events. Results We succeeded in the implementation of catheter radiofrequency catheter ablation combined with left atrial appendage occlusion. No pericardial effusion or other intraoperative complications were observed. During the follow-up, the patient presented no palpitations, short breath, left atrial appendage occluder thrombus, or residual shunt. Gingival bleeding occured during dual antiplatelet therapy and was stopped when aspirin discontinued. Conclusion It is feasible and safe for patients with persistent atrial fibrillation to receive the combinational therapy of radiofrequency catheter ablation and left atrial appendage occlusion when there are interventional indications.