Objective To compare the therapeutic efficacy of divided transurethral enucleation of the prostate with transurethral enucleative resection of prostate on large benign prostate hyperplasia(volume>100 mL). Methods A set of review dataon 208 large volume prostate patientsfrom January 2010 to January 2015 was used. The clinical cases respectively were divided into transurethral enucleation of the prostate(102 cases)and TUERP(106 cases). In the two groups the following data were analyzed: age, body mass index, prostate volume, HB level, residual urine volume,large urinary flow rate, quality of life score, perioperative International Prostate Symptom Score(IPSS),perioperative conditions were recorded. 3,6, 12 montes,patients IPPS score, Qmax, RUV, QOL, retrograde ejaculation, sexual function, incontinence and other indicators situation were recorded. Results Patients were followed up for 12-24 months, and median follow-up time was 14 months. After 3, 6 and 12-month follow-up process, both sets of postoperative IPSS score, Qmax, RUV, QOL showed no significant difference. Early post-surgery, in the divided enucleation group, the urinary incontinence was lower than that in TUERP group. However, there were no significant difference in long-term urinary incontinence. In retrograde ejaculation connection, the divided enucleation group was better than TUERP group after 3, 6, 12-month follow-ups. Conclusions Divided transurethral enucleation forthe volume>100 mL BPH has a better efficacy and safety than TUERP.