Objective To investigate the perioperative treatment method of artificial hip replacement for cirrhotic patients. Methods From June 2008 to December 2014, 16 patients with cirrhosis parallel caused by various reasons underwent hip replacement surgery, including 14 males and 2 females, aged(55.4±9.1)years( range from 41 to 64.5 years). There were 12 cases of femoral head necrosis, 4 cases of femoral neck fracture; 14 cases of alcoholic cirrhosis. Two cases of cirrhosis of the liver were caused by hepatitis B virus; 11 cases were classified as Child-Pugh class A, 4 case were classified as grade B, 1 case was classified as grade C, all were unilateral. Paired by gender, height, weight, disease and 1:2 ratio, 32 cases were collected in the control group for the same period, with femoral neck fracture and femoral head necrosis undergoing artificial hip replacement, including 28 male patient and 4 female patients, of age(57.4±10.2)years(range from 47.2 to 67.6 years). Femoral head necrosis were presented in 24 cases, femoral neck fracture in 8 cases. Both groups were observed for complications, preoperative and postoperative Harris score and functional evaluation and follow-up for at least one year, while retaining debridement prosthesis patients were followed for at least 2 years. Results In the cirrhosis group(group A)there were 7 cases of postoperative Child-Pugh class A, 8 cases of grade B, 1 case of grade C; in the control group(group B), no cirrhosis occurred. There were six cases of postoperative wound exudate in Group A, while there was no superficial wound infection, peripheral hematoma, or postoperative joint infections in Group B. The patients with superficial wound infection were given clear Chong dressing and antibiotics and thewound healed. Four patients were with hematoma Five with acute peripheral prosthesis infection, including Staphylococcus epidermidis infection in 4 cases, underwent debridement and retention of prosthesis then were followed up for 2 years without recurrence, no prosthesis loose. Staphylococcus aureus infection occurred in 1 case, for whom debridement and retention of prosthesis failed. Group A in hospital stay, operative time, and the total cost outperformed group B significantly(P<0.05). Conclusion Detailed preoperative preparation is needed for the artificial joint replacement in patients with cirrhosis, since risk is higher for more postoperative complications,especially infections and bleeding than patients without cirrhosis.