bjective To explore the distribution characteristics of the rs1491034 and rs982873 single nucleotide polymorphisms(SNPs)in Guangxi populations, and to compare their genotype and allele frequency with different races and populations of other regions. Methods The SNPs of rs1491034 and rs982873 were detected by SNaPshot SNP and DNA sequencing methods. We statistically analyzed the difference between the genotype and allele frequency of the two SNPs that we studied and compared it with the data of different races and regional populations, while were published in the international HapMap project. Results The rs1491034 and rs982873 SNPs contain TT, TC and CC genotypes, respectively, in the Guangxi population. The genotype and allele distribution of the two SNPs were not significantly different between genders in the Guangxi population(P>0.05). The genotype and allele distribution of the rs1491034 SNP were significantly different from HapMap-CEU and HapMap-YRI populations(P<0.01), and the genotype and allele distribution of the rs982873 SNP were significantly different from HapMap-JPT and HapMap-YRI populations(P<0.05). However, the genotype and allele distribution of the two SNPs were not significantly different compared with other listed population. Conclusion There are rs1491034 and rs982873 SNPs in the Guangxi population, and there are varying degree of differences in the genotype and allele distribution of the two polymorphism between the Guangxi populations and other published populations of races/regions.