甲状腺乳头状癌(cN1b)Ⅶ区淋巴结转移危险因素及规律分析
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作者单位: 福建医科大学 附属第一医院甲状腺乳腺科,福州 350005 1.甲状腺乳腺科; 2.化疗科

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R322.25; R730.261; R736.1

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基金项目: 国家临床重点专科建设项目(国卫办医函2013544号); 福建省自然科学基金面上项目(2017J11089) 作者简介: 曹永晋,男,主治医师,医学硕士 通讯作者: 蔡伟华. Email: 547588504@qq.com


Risk Factors Analysis for Level Ⅶ Lymph Node Metastasis in Papillary Thyroid Carcinoma(cN1b)
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1. Department of Thyroid and Breast Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China; 2. Department of Chemotherapy, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China

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    摘要:

    目的 探讨甲状腺乳头状癌(cN1b)颈部Ⅶ区淋巴结转移的危险因素及转移规律。 方法 回顾性分析初治的134例甲状腺乳头状癌(cN1b)行Ⅱ~Ⅶ区的功能性颈淋巴结清扫的患者,通过χ2检验、多因素Logistic回归分析,比较颈部Ⅶ区淋巴结转移与临床病理因素的相关性。 结果 颈部Ⅶ区淋巴结转移率为53%。单因素分析显示,肿瘤T分期(P<0.001,χ2=31.897)、Ⅵ区淋巴结转移(P<0.001,χ2=17.743)、颈侧区淋巴结转移(P=0.032,χ2=4.773)与Ⅶ区淋巴结转移相关,差别具有统计学意义; 多因素分析显示,肿瘤T分期(P=0.001)和Ⅵ区淋巴结转移(P=0.018)是影响颈部Ⅶ区淋巴结转移的独立危险因素。 结论 甲状腺乳头状癌(cN1b)患者有较高的Ⅶ区淋巴结转移率,若存在危险因素建议行Ⅶ区淋巴结清扫术。

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    ABSTRACT: Objective This study was to analyze the risk factors of level Ⅶ lymph node metastasis for patients with papillary thyroid carcinoma(PTC)(cN1b). Methods 134 cases of papillary thyroid carcinoma(cN1b)who underwent level Ⅱ-Ⅶ lymph node dissection were analyzed retrospectively. Clinical and pathologic data were collected from patients who were first diagnosed as papillary thyroid carcinoma. Chi-square test and multivariate logistic regression analysis were used to identify the risk factors of the level Ⅶ lymph node metastasis. Results The Ⅶ lymph node metastasis rate of PTC patients was 53%. Univariate analysis indicated that tumor T staging(P<0.001,χ2=31.897), level Ⅵ lymph node metastasis(P<0.001,χ2=17.743), and lateral lymph node metastasis(P=0.032,χ2=4.773)were significantly correlated with level Ⅶ lymph node metastasis. Multivariate logistic regression analysis indicated that tumor T staging(P=0.001)and level Ⅵ lymph node metastasis(P=0.018)independently correlated with level Ⅶ lymph node metastasis. Conclusion The(cN1b)PTC has a high rate of pathological lymph node metastasis, It is important to conduct the level Ⅶ lymph node dissection for the PTC(cN1b)patients with the risk factors.

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曹永晋, 蔡伟华, 郑敏, 王宗财.甲状腺乳头状癌(cN1b)Ⅶ区淋巴结转移危险因素及规律分析[J].福建医科大学学报自然版,2018,(1):33-37

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