ObjectiveTo compare the hypoglycemic effect of extractions from four strains of Ficus carica leaves and to investigate their mechanism.MethodThe model of type 1 diabetes was established by intraperitoneal injection of STZ 150 mg/kg.The diabetic mice were randomly divided into five groups: model group, Zi Guo group, Japanese Zi Guo group, Mei Liya group, and Feng Can Huang group.The daily dosage of 2 g/kg Ficus carica leaves extract was administered for 6 weeks.Fasting blood glucose (FBG), serum triglyceride (TG), and cholesterol (TC) levels in mice were measured and their effects on liver glycogen and glucose-6-phosphatase were investigated.ResultsBlood glucose in all four groups intervened with different strains of Ficus carica leaves significantly decreased （P＜0.01） and triglyceride levels in Feng Chan Huang, Zi Guo, and the Japanese Zi Guo groups significantly reduced （P＜0.01）.The level of liver glycogen was decreased in Feng Can Huang group（P＜0.05） and liver glucose-6-phosphorylase was also decreased in Zi Guo and Mei Liya group（P＜0.01）.ConclusionsThere are some differences in the blood glucose, serum lipid， and gluconeogenesis between the four strains of Ficus carica leaves extract.