ObjectiveTo investigate the associations between polymorphisms in CYP11B2-344 T/C gene and coronary heart disease (CHD) in Tangshan.MethodsA case-control study was conducted to select patients who were consecutively admitted to Department of Cardiology, Affiliated Hospital of North China University of Science and Technology from March 2012 to February 2014.Coronary heart disease was diagnosed based on quantitative coronary angiography (QCA).The gender, age, history of smoking, drinking, hypertension, diabetes mellitus, family situation, and drug use were recorded.Low-density lipoprotein cholesterol（LDL-C）, lipoproein (a)（LPa）, apoliporotein-A（APOA）, high-density lipoprotein cholesterol（HDL-C）, total cholesterol（TC）, triglycerides（TG）, apoliporotein-B （APOB） wered measured.Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect the genotypes of aldosterone synthase CYP11B2-344 T/C.ResultsIn population studed three genotype frequencies of TT, TC, CC were 48.5%, 42% and 9.5%, while T allele frequency was 69.5%, and C allele frequency was 30.5%.The frequencies of three genotypes in patients with coronary heart disease were 45.2%, 45.2% and 9.6%.T, C allele frequencies were 67.8%, 32.7%.The frequencies of TT, TC, CC, TC + CC genotypes in coronary heart disease group, compared to control group, showed no differences.The levels of LPa, male, smoking, history of hypertension, and diabetes mellitus in coronary heart disease group were higher than those in control group.The levels of APOA and HDLC in coronary heart disease group were lower than those in control group.For the levels of APOA, HDL-C, TG, LDL-C and APOB, there was no differences between the two groups.ConclusionsThe CYP11B2-344 T/C is not significantly associated with coronary heart disease in the study.LPa, male, smoking, hypertension, and diabetes are independent risk factors for coronary heart disease.APOA is a protective factor for coronary heart disease.