Objective To investigate the clinical value of application of enhanced recovery after surgery(ERAS)on percutaneous nephrolithotomy(PCNL)during peri-operative period. Methods From September 2016 to December 2017, the clinical data of 135 cases of percutaneous nephrolithotomy patients in our department were reviewed, and the cases were divided into ERAS group and regular group based on whether they were treated with ERAS or not. ERAS group patients were managed with ERAS while the regular group patients were managed with conventional method. After operation, the first drinking time, the first exhaust time, VAS score, the first bed activity time, time of indwelling catheter, incidence of complication and hospital day of the two groups were compared. Results The first drinking time, the first exhaust time, the first bed activity time, time of indwelling catheter, hospital day in the experimental group were significantly shorter than that in the regular group(P<0.05). 24 hours and 48 hours after operation, the VAS score of ERAS group were significantly lower than that of regular group(P<0.05). Conclusion Application of ERAS in PCNL can enhance the recovery and improve prognosis. It is worth to be applied.