ObjectiveTo observe the difference in MRI image and ultra\|structure in cerebral artery occlusion (MCAO) model and the photochemical induced focal cerebral infarction model in the rat brain.MethodsThe model of MCAO and photochemical induced focal cerebral infarction rats were established separately, and the ischemic area and cortical vessels distribution were observed by small animal magnetic resonance imaging system, and the ultra\|structural changes of the two models were compared with transmission electron microscopy (TEM).ResultsThe infarct area of MCAO model rat was large and unstable, the cell structure was destroyed seriously, while the vascular deformation was remarkable with few neovascularization.Whereas the infarct area of brain by photochemical induced method was small and stable, the cell structure damage was not serious, and there were more new blood vessels.ConclusionThe two model methods have the advantages and disadvantages, which can provide a practical tool for the protection of blood vessel injury after cerebral infarction and the thrombolytic therapy, and they may be used to select the appropriate model according to the demand of scientific research