ObjectiveTo investigate the correlationship between the expression of GATA binding protein 3(GATA3)and clinicopathological parameters in breast neoplasms, and to further explore the expression of GATA3 in breast cancer tissues with different molecular types and its prognostic significance.MethodsThe clinicopathological data of 209 patients with breast cancer were analyzed retrospectively.The expression of GATA3, ER, PR, Her-2, AR and Ki-67 were evaluated by immunohistochemical staining assays.The expression of GATA3 in different molecular types of breast neoplasms were then assessed using the Chi-square test.The Kaplan-Meier method was used for the analysis of survival. ResultsLow expression of GATA3 in breast cancer tissues was associated with low tumor differentiation, lymph node involvement, late TNM staging(P<0.05).There was a positive correlation between GATA3 expression and ER, PR and AR expression in breast cancer tissues.There was a negative correlation with Ki-67 proliferation index, and the differences were statistically significant(P<0.05).The expression rate of GATA3 in triple negative breast cancer(17.5%)was lower than that in non-triple negative breast cancer(71.0%)(P<0.05).The expression rates of GATA3 in Luminal A, Luminal B, Her-2 overexpression and triple negative breast cancer tissues were 89.8%, 79.1%, 43.4% and 17.5%, respectively.In different clinical stages of Luminal breast cancer, the disease-free survival time of patients in GATA3(+)group was significantly longer than that in GATA3(-)group(all P<0.05).ConclusionThe expression of GATA3 is related to the molecular typing of breast neoplasms and involves in the development and metastasis of breast cancer, which can be used as an auxiliary index to predict the prognosis.