Objective To explore the effect of Receptor for adcanced glycation end products(RAGE) inhibitor FPS-ZM1 on the expression of high mobility group box-1(HMGB1) and Thioredoxin(TRX) in the brain of young rats with chronic epilepsy induced by pentylenetetrazole and the intervention of NGF. Methods 130 clean level of male Wistar rats were randomly divided into group A (normal control group), group B (epilepsy control group), and group C (mNGF epilepsy intervention group)，group D (FPS-ZM1 epilepsy intervention group), the rats were intraperitoneal injected with pentylenetetrazol 40 mg/kg to establish an epilepsy model. After successful modeling, groups A and B were given equal doses of normal saline, group C were given mNGF 4ug /kg, and group D were given FPS-ZM1 1 mg/kg by intraperitoneal injection for 7 days. The hippocampus was isolated at 3, 24 and 72 h after the intervention，rats were anesthetized by intraperitoneal injection of pentobarbital. The expression of HMGB1 in hippocampus was determined by Western-blot method, and the content of TRX was detected by ELISA. Results There was no seizure in group A，the expression level of HMGB1 in hippocampus was significantly lower than that in group B at different time points，the TRX content was higher than that in group B(P＜0.001). The expression level of HMGB1 in group C and group D were lower than those in group B at different time points, the TRX content were higher than group B, the difference was statistically significant (P<0.05); The expression level of HMGB1 in group D was decreased at 3 h and 24 h compared with group C, the difference was statistically significant (P<0.05);And there was no significant difference between 72 h in this two groups (P>0.05). Conclusion Both FPS-ZM1 and mNGF could reduce the cerebral inflammatory reaction and oxidative stress in the early stage of epilepsy young rats, which may play an important role in brain protection.