Objective To investigate the application of laparoscopic pelvic lymph node dissection combined with inguinal lymph node dissection in the treatment of metastatic melanoma lymph node.Methods Retrospective analysis was performed on 15 patients with ipsilateral pelvic iliac paravascular and/or inguinal metastatic melanoma lymph node admitted to Fujian Cancer Hospital from August 2017 to August 2020. The primary lesions were all from ipsilateral lower extremities.The operation was performed by laparoscopic pelvic lymph node dissection and then laparoscopic pelvic lymph node dissection in the inguinal region.Result All the 15 operations were completed successfully. The mean operative time was (177.2±28.17)min, the mean intraoperative blood loss was (51.67±25.14)ml, the mean postoperative activity time was (4±1.26)d, and the mean postoperative hospitalization time was (8±1.10)d. There was 1 case of lower limb thrombosis, 1 case of inguinal lymphatic leakage and 1 case of pulmonary infection.There were no other complications. Pathological examination confirmed periiliac lymph node and/or inguinal lymph node metastasis.Conclusion Laparoscopic pelvic lymph node dissection combined with inguinal lymph node dissection is a clear and feasible surgical method for the treatment of ilioinguinal metastatic melanoma lymph node,This operation has a wide range of lymph node dissection, complete dissection, less trauma, quick recovery, less complications, It has a high clinical promotion value.