Abstract Objective: To explore prognostic factors for postoperative endometrial carcinoma patients and to establish a prognostic index model, so as to provide a scientific basis for improving the survival of patients with endometrial carcinoma surgery. Methods: Collecting and analyzing the clinical pathology and survival data of 270 cases of endometrial carcinoma confirmed by the First Affiliated Hospital of Fujian Medical University. The Kaplan-Meier was used to calculate the survival rate of patients and the survival curves were drawn. Independent risk factors of postoperative death were analyzed by Cox regression model with single factor and multiple factors. The best cut-off point. of prognostic index score was established and selected by X-tile method. Results: During a follow-up of 98 months .The survival time was 3-98 months and the median survival time was 44.5 months. Multivariate analysis showed that family history of cancer (X1), pathological type (X2) and extrauterine invasion (X3) were independent risk factors for endometrial carcinoma death (P <0.05). The prediction model was: PI = 1.981*X1+2.191*X2+2.510*X3. The best cut-off points of the index of prognosis index by X-tile method was 1.980. Conclusion: Patients with endometrial carcinoma who are associated with high risk factors such as familial history of tumor, non-endometrioid adenocarcinoma and extrauterine invasion should be given high priority in clinical practice. To develop a comprehensive treatment, while strengthening its follow-up and monitoring.