显微手术治疗重症动脉瘤性蛛网膜下腔出血临床预后影响因素分析
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1.福建医科大学附属协和医院;2.宁化县总医院

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Analysis of Risk Factors for Clinical Prognosison of Patients with Severe Aneurysmal Subarachnoid Hemorrhage Treated by Surgical Clipping
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    摘要:

    目的 分析显微手术治疗重症动脉瘤性蛛网膜下腔出血(SaSAH)患者预后的影响因素。 方法 回顾性分析2010年1月—2020年1月67例SaSAH患者的临床资料,经数字减影血管造影(DSA)或CT血管成像(CTA)证实为单发颅内责任动脉瘤且经头部CT证实有蛛网膜下腔出血,对SaSAH患者行动脉瘤手术夹闭术治疗,术后予营养支持、营养神经等治疗。根据患者出院后1年的格拉斯哥评分(glasgow outcome scale,GOS)评估预后,并分为预后良好组(39例)和预后不良组(28例)。记录两组患者的临床资料[性别、年龄、责任动脉瘤部位、Hunt-Hess分级、高血压病史、糖尿病史、吸烟史],并进行组间比较。对SaSAH患者临床预后影响因素进行单因素分析和多因素分析。 结果 单因素分析显示,年龄、Hunt-Hess分级是SaSAH患者临床预后的影响因素(P<0.05),性别、高血压病、糖尿病、吸烟史、责任动脉瘤部位不是SaSAH患者临床预后的影响因素(P>0.05)。多因素分析显示,年龄高低和Hunt-Hess分级是SaSAH患者临床预后的影响因素(P<0.05)。年龄≥60岁的SaSAH患者临床预后差的风险是年龄<60岁的SaSAH患者的5.430倍。Hunt-Hess分级每增加1个单位,SaSAH患者临床预后差的风险增加3.231倍。 结论 与低龄和低级别SaSAH患者,高龄和高级别Hunt-Hess分级的SaSAH患者预后较差。临床中遇到高Hunt-Hess分级或高龄的SaSAH患者时,术前需进行详细评估,制订个体化、针对性强的治疗方案,尽可能降低不良临床预后的发生率。

    Abstract:

    Objective This study analyze the risk factors of Clinical Prognosison in patients with SaSAH treated by surgical clipping. Methods From January 2010 to January 2020, 67 cases of SaSAH patients diagnosed by DSA or CTA and subarachnoid hemorrhage diagnosed by head computed tomography (CT). Intracranial aneurysm was treated by surgical clipping followed by nutritional support, neurocritical care and management. Follow up was performed 1 year after discharge by recording GOS, and the patients were divided into good prognosis group (39 cases) and poor prognosis group (28 cases). Results Univariate analysis showed that age and Hunt and Hess Scale were the risk factors of clinical prognosis in patients with SaSAH (P<0.05). Gender, hypertension, diabetes, smoking history and location of responsible aneurysms were not the factors influencing the prognosis of SaSAH patients (P>0.05). Multivariate analysis showed that age and Hunt and Hess Scale were the risk factors of clinical prognosis in patients with SaSAH (P<0.05). The risk of poor clinical prognosis in SaSAH patients aged ≥60 years was 5.430 times higher than that in SaSAH patients aged <60 years. The risk of poor clinical prognosis in patients with SaSAH increased by 3.231 times for each additional unit of Hunt and Hess Scale. Conclusion Compared with low age and low Hunt-Hess grade SaSAH patients, venerable age and high Hunt-Hess grade indicate poor prognosis. When SaSAH patients with high Hunt-Hess grade or venerable age are encountered in clinic, a comprehensive evaluation needs to be carried out before operation, and an individualized and targeted treatment plan should be formulated to reduce the incidence of adverse clinical prognosis as much as possible.

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陈建屏,林祺,张志鹏.显微手术治疗重症动脉瘤性蛛网膜下腔出血临床预后影响因素分析[J].福建医科大学学报自然版,2021,55(6):

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  • 收稿日期:2021-09-08
  • 最后修改日期:2021-11-23
  • 录用日期:2021-12-30
  • 在线发布日期: 2022-03-04
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