Objective To investigate the prevalence of hyperuricemia (HUA) among permanent residents in Gaoshan, Fuqing, and to explore the related factors of HUA . Methods Data from residents who participated in Fuqing Cohort Study in 2019 was collected. The prevalence of HUA in different groups was calculated and logistic regression model was used to analyze the related factors of HUA. Results Of 5 172 residents, 34.05% residents were male and 79.95% residents aged over 50 years. The age-standardized prevalence of HUA was 31.04% and it was significantly higher in males than that in females (42.47% vs 27.36%). The prevalence of HUA increased with age in females. Presence of coronary heart disease, body mass index (BMI), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) and creatinine (Cr) had positive correlation and fasting plasma glucose had negative correlation with HUA in males. Age, BMI, TG, LDL-C and Cr had positive correlation and high-density lipoprotein cholesterol had negative correlation with HUA in females. Conclusions The prevalence of HUA among permanent residents in Gaoshan, Fuqing was higher than the average level of Fujian province (24.7%). HUA was related to dyslipidemia, abnormal blood glucose, overweight/obesity, prevalent coronary heart disease and abnormal renal function.